Influence of anterior thalamic nucleus deep brain stimulation on cognitive ability of epilepsy patients and relevant factor analysis
Pan Junhong
Gu Jingjing
Guan Yuguang
Luan Guoming
Zhou Jian
Abstract：Objective To explore the influence of anterior thalamic nucleus deep brain stimulation (ANT-DBS) on cognitive ability of epilepsy patients and the relevant factors. Method Clinical data of 15 epilepsy patients undergoing ANT-DBS were analyzed respectively. The McHugh classification was uesd to evaluate the surgical outcome, the Wechsler intelligence scale (WAIS-Ⅳ) score , Montreal cognitive assessment ( MoCA ) and Center for epidemiological survey depression scale ( CES-D ) were used to evaluate the cognition and emotion before and after surgery. The factors related to cognitive ability were analyzed. Results Fifteen patients were followed up for 1 to 1.5 years, satisfactory results of controlling seizure was achieved in 4 patients and non-satisfactory results in 11. The postoperative visuospatial and executive function, naming, memory, attention, language, abstraction, orientation and memory quotient were higher than preoperative results (P<0.05). The cognitive improvement was positively correlated with the onset age (r=0.427, P=0.031), negatively correlated with course of disease (r=-0.723, P=0.002) and frequency of seizure (r=-0.315, P=0.040). There was no significant correlation between cognition and seizure reduction, seizure types and drug categories (P> 0.05). Conclusion ANT-DBS can obviously improve the cognitive ability of epilepsy patients, thus being considered as a treatment mean of epilepsy, especially for the intractable epilepsy patients without surgical indication.
Keywords：epilepsyrefractorydeep brain stimulationanterior nuclei of thalamuscognitiveintelligencedepression
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 14-16 )