Correlation study between peritumoral brain edema and tumoral location, pathological grading and Ki-67 expression in meningioma

Yuan Junhui; Shi Dongfu; Lv Yansong; Ji Junling; Liu Baiyun; Wu Zhen

doi:10.11850/j.issn.1009-122X.2017.12.009

Abstract：Objective To analyze the relationship between peritumoral brain edema (PTBE) and tumoral location,pathological type,Ki-67 expression in meningioma.Methods Clinical data of 712 patients with meningioma were analyzed retrospectively,and the statistical analysis was used to evaluate the differences of PTBE incidence and severity degree in different situation.Results PTBE occurred in 358 patients (50.3％).The incidence rate of PTBE in basicranial meningioma was higher than that in non-basicranial meningioma (x2 =14.686,P＜ 0.01),and the edema was much more severe,too (x2 =16.812,P＜ 0.01).The incidence rate of PTBE in WHO grade Ⅱ was higher than that in WHO grade Ⅰ (x2 =32.403,P ＜ 0.01),and the same to WHO grade Ⅲ versus grade Ⅱ meningiomas (x2 =21.356,P ＜ 0.05),moreover,edema degree showed significant differences between different pathological grades of the tumor (x2 =40.482,P ＜ 0.01).In addition,the total incidence rate of PTBE in angiomatous type,microcystic type,secretory type and lymphoplasmacyte-rich type meningiomas was much higher than that in the other five pathological types in WHO grade Ⅰ meningioma (x2=48.078,P ＜ 0.01),even was close to the total incidence rate of WHO grade Ⅱ and Ⅲ meningiomas (x2 =3.238,P ＞ 0.05).Furthermore,the level of Ki-67 showed an increasing trend with the severity degree of PTBE (x2 =33.359,P ＜ 0.01),and logistic regression analysis showed a positive correlation between both pathological grading and Ki-67 distribution and the severity of PTBE (P ＜ 0.01).Conclusion The incidence and severity of PTBE can reflect the tumor malignancy grade and Ki-67 expression to a certain extent in meningiomas,and can provide a important reference for operative plan,preoperative treatment and postoperative adjuvant therapy.