Influence of surgical resection extent on the prognosis of patients with high-grade gliomas:a single center study with 303 cases
Li Ling
Zou Shucheng
Luo Zongwan
Li Chuanghua
Liu Bo
Liu Kun
Zhang Weimin
Liu Hua
Huang Hongxing
Abstract：Objective To investigate the influence of surgical resection extent on the prognosis of patients with high-grade gliomas.Methods Clinical data of 303 patients with high-grade gliomas were analyzed retrospectively,including 126 anaplastic gliomas (WHO grade]) and 177 glioblastomas (WHO grade Ⅳ).Isocitrate dehydrogenase (IDH) gene was detected,and the relationship between clinical data and overall survival (OS) was analyzed statistically.Results The univariate analysis indicated that the better OS was associated with age less than 55 years,complete radio-and chemotherapy,IDH-1R132H mutations,preoperative KPS more than 70 points and total tumor resection (P ＜ 0.05).Kaplan-meier survival curve showed that the higher the tumor resection extent,the better the patient's prognosis (P ＜ 0.05).In the multivariate analysis,age,tumor grade,surgical resection extent,complete radio-and chemotherapy and IDH-IR132H gene type were all independent prognostic factors (P ＜ 0.05).Conclusions High-grade gliomas with poor prognosis require a combination treatment of surgery,radiotherapy and chemotherapy.Besides,total tumor resection is of great significance in improving OS and life quality for patients with high-grade gliomas.
Keywords：gliomasdegree of tumor resectionisocitrate dehydrogenaseoverall survival
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 544-547 )