Long-term follow-up study of subthalamic nucleus stimulation for primary dystonia
Jiang Jianxin
Pan Yixin
Wang Xiaolin
Cao Chunyan
Li Dianyou
Zhan Shikun
Pan Sijian
Zhang Jing
Sun Bomin
Lu Jun
Abstract：Objective To investigate long-term efficacy of subthalamic nucleus deep brain stimulation (STN-DBS) for the treatment of primary dystonia.Methods Clinical data of 34 patients with primary dystonia receiving bilateral STN-DBS treatment were analyzed retrospectively.All the patients were evaluated with Burke-Fahn-Marsden dystonia rating scale (BFMDRS) and 36-item short form (SF-36) of health survey before surgery and 1,12,24 months after surgery.The mean follow-up time was 5.5±2.5 years,ranged from 2 to 10 years,and 19 patients were followed up more than 5 years.Results All the patients experienced a remarkable long-term and stable improvement after stimulation.The motor scale of BFMDRS and SF-36 scores significantly improved 1 month after stimulation (P ＜ 0.05),further improved 12 months after simulation (P ＜ 0.05),and kept stable after 12 months.The adverse events included misplacement or breakage of the electrode,implant rejection and sustained depression.Conclusions STN-DBS implantation is significantly effective for primary dystonia,can significantly improve the motor symptoms and quality of life,and maintain stable long-term efficacy and longer working life.
Keywords：primary dystoniasubthalamic nucleusdeep brain stimulation
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 533-536 )