Expression and significance of plasma VEGF in patients with ischemic stroke
Zhao Gang
Liang Junchao
Yang Huan
Quan Jingwen
Liu Xiaoyan
Abstract：Objective To explore the expression level and clinical significance of plasma vascular endothelial growth factor (VEGF) in ischemic stroke and its several subtypes. Methods One hundred and seventy-one patients with ischemic stroke were selected as stroke group, which were divided into four subtypes including atherothrombotic infarction (ATBI, n=34), small artery disease (SAD, n=45), cardioembolic infarction (CE, n=49) and other types (OT, n=43). Healthy subjects were age-and gender-matched with stroke group and served as control group (n=171). Plasma VEGF level was measured by ELISA 1 d, 3 d, 7 d, 14 d, 90 d after stroke and analyzed. Results Compared with control group, the expressions of plasma VEGF in stroke group were higher 1 d after stroke and lasted to 90 d after stroke (P<0.05). The expressions of plasma VEGF in ATBI, CE, SAD and OT were obviously higher (P<0.05). The VEGF level was positively correlated with NIHSS in CE patients (r=0.843, P<0.05). Compared with plasma VEGF of patients with good outcome 90 d after stroke, the plasma VEGF of patients with bad outcome significantly increased in the stroke group, SAD and CE subtypes (P<0.05), but significantly decreased in ATBI subtype (P<0.05) and remained unchanged in OT subtype (P>0.05). Conclusion The expression of plasma VEGF would increase in all subtypes of ischemic stroke. The plasma VEGF level has different correlations with prognosis of all subtypes.
Keywords：cerebrovascular accidentstrokeischemicvascular endothelial growth factorenzyme-linked immuno sorbent assay
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 437-439 )