Comparison of efficacy and safety between hippocampal transection and selective amygdalohippocampectomy
Wang Wei
Zhao Quanjun
Yin Feng
Wang Tao
Cui Shaojie
Shi Tiejun
Wang Peixin
Li Lianfeng
Hei Bo
Abstract：Objective To compare the surgical outcome and its influences on cognition and memory of hippocampal transection and selective amygdalohippocampectomy for intractable medial temporal lobe epilepsy. Methods Clinical data of 19 patients with intractable medial temporal lobe epilepsy were analyzed retrospectively, including 8 patients receiving hippocampal transection (observation group) and 11 receiving selective amygdalohippocampectomy (control group). The seizure control rate after surgery and neuropsychological examinations before and after surgery were analyzed and compared. Results There was no significant difference in seizure control rates between two groups (P>0.05). There was no significant difference in performance intelligence quotient (PIQ), verbal intelligence quotient (VIQ), full intelligence quotient (FIQ) and memory quotient (MQ) before and after surgery in observation group (P>0.05). The PIQ, FIQ and MQ after surgery in control group were obviously lower than those before surgery (P<0.05). There was significant difference in MQ differentials before and after surgery between the two groups (P<0.05). Conclusion Hippocampal transection can effectively control seizure, make little damage to the function of neuropsychology and especially can well preserve the memory function.
Keywords：epilepsymedial temporalintractablehippocampal transectionamygdalohippocampectomyselectiveneuropsychologicalmemory
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 433-436 )