Efficacy analysis of microsurgery for intra-suprasellar craniopharyngioma by endonasal transsphenoidal approach
Yang Qiquan
Li Song
Zhang Yin
Mi Xiang
Hu Jintao
Duan Lian
Shen Rufei
Yang Hui
Abstract：Objective To explore the therapeutic effect of microsurgery for intra-suprasellar craniopharyngioma via endonasal transsphenoidal approach.Methods Clinical data of 10 patients with intra-suprasellar craniopharyngioma were analyzed retrospectively,who consisted of 4 juveniles and 6 adults.Microsurgery by endonasal transsphenoidal approach was performed in all the patients.Then,clinical symptoms and hormone levels before and after operation were compared.Results Total tumor removal was achieved in 8 patients and subtotal removal in 2,of the latter two,one was treated by gamma knife and the other by endonasal transsphenoidal surgery again.Pituitary stalks were intact in all the patients.One patient died of electrolyte disturbances 1 month after operation,and another was lost to fo11ow-up 4 months after operation.The clinical symptoms were improved to different degrees in most patients after the operation.Endocrine hormones decreased in 8 patients,and all of them were given hydrocortisone and levothyroxine sodium,while there was no significant difference between predose and maintenance dose (P ＞ 0.05).During the follow-up period of 1 year,no tumor recurred.Conclusions Microsurgery by endonasal transsphenoidal approach have advantages with less trauma,short operation time,high resection rate,fewer postoperative complications for intra-suprasellar craniopharyngioma,and can obviously improve clinical symptoms.Moreover,it should be emphasized that the standardized long-term follow-up and appropriate hormone replacement therapy are necessary,for improving the quality of life in postoperative patients.
Keywords：craniopharyngiomaintra-suprasellar typeapproachendonasal transsphenoidalmicrosurgery
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 396-399 )