Effect of Ginkgo biloba extract on neurological function in Alzheimer's disease modal rats
Yu Yan
Wu Zhifeng
Qin Yihui
Li Yi
Abstract：Objective To investigate the effects of Ginkgo biloba extract (GBE) on learning and memory behaviors,oxyradical of the hippocampus tissue and endoplasmic reticulum stress (ERS) response in Alzheimer's disease (AD) model rats.Methods AD model rats were established by intraperitoneal injection of D-galactose.The 15 months old Wistar rats were randomly and equally divided into 4 groups:control group,AD group,AD + GBE group and ERS activator tunicamycin (Tm) group (AD + GBE + Tm group).The learning and memory behaviors were examined by the Morris water maze.The superoxide dismutase (SOD) activity and malondial ()(MDA) content of the hippocampus tissue were detected by kit.Activating transcription factor 6 (ATF-6) and C()T()ancerbinding protein homologous protein (CHOP) were tested with Western blotting.Results Compared with the control g()p,the escape latency was prolonged,while the distance percentage in target quadrant was decreased,and the expressions of MDA,SOX,ATF-6 and CHOP were up-regulated in the other three groups (P ＜ 0.05).Compared with the AD group,the escape latency was obviously shortened and the distance percentage in target quadrant was increased,meanwhile,SOD expression was up-regulated,and the expressions of MDA,ATF-6 and CHOP were down-regulated in the AD + GBE group (P ＜ 0.05).Compared with the AD + GBE group,SOD expression was down-regulated and the expressions of MDA,ATP-6 and CHOP were up-regulated (P ＜ 0.05).Conclusions GBE can inhibit ERS response and suppress the generation of oxyradicals,which can improve learning and memory behaviors of AD modal rats and relieve the disease condition.
Keywords：Alzheimer's diseaseGinkgo biloba extractendoplasmic reticulum stressneuroprotectionrats
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 275-278 )