Study of blood pressure variability in the acute phase of aneurysmal subarachnoid hemorrhage

Wang Hongqin; Chen Guangzhong; Qin Kun; Peng Chao

doi:10.11850/j.issn.1009-122X.2017.06.003

Abstract：Objective To analyze the characteristics of blood pressure variability (BPV) in the acute phase of patients with acute aneurysmal subarachnoid hemorrhage (aSAH) exploring the clinical values of ambulatory blood pressure monitoring (ABPM).Methods Clinical data of 370 patients with acute aSAH were analyzed retrospectively,who received ABPM.The re-rupture after admission occurred in 15 patients,who were set as re-rupture group,and the remaining 355 patients as non-rupture group.The mean systolic blood pressure (mSBP),mean diastolic blood pressure (mDBP) and BPV after admission and modified Rankin Scale on discharge were comparatively analyzed between patients in the re-rupture group and non-rupture group.Results The mSBP was (138.7 ± 12.6) mmHg in the re-rupture group 24 h after admission,which was significantly higher than 127.4 ± 10.1 in the non-rupture group (P =0.000).But there was no significant difference in mDBP between the re-rupture and non-rupture groups (P =0.224).The BPV results showed that systolic BPV and diastolic BPV were 12.8％ ± 7.7％ and 11.9％ ± 7.3％ respectively in the re-rupture group,which were higher than 10.5％ ± 6.4％ and 9.3％ ± 5.4％ in the non-rupture group (P =0.000,0.035).The modified Rankin Scale score at discharge was better in non-rupture group than in re-ruptured group (P =0.000).There were significant differences in mSBP and systolic BPV between the different grades of prognosis (P ＜ 0.05).Conclusion For aSAH patients in the acute phase,the SBP and BPV has great influence on re-rupture of aneurysm and prognosis,and ABPM has important clinical values.