Correlation study of the dynamic changes of serum insulin-like growth factor-1 and cognitive dysfunctions in patients with acute traumatic brain injury
Guo Yijun
Zheng Ping
Tong Wusong
Yang Wenjin
Wang Ruizhong
Jiao Ronghong
He Bin
Kuang Zhucai
Wu Chenxing
Chen Lei
Zhao Chunfang
Ni Ping
Abstract：Objective To investigate the correlations between dynamic changes of serum insulin-like growth factor-1 (IGF-1) and the cognitive dysfunction in acute traumatic brain injury (TBI).Methods Eighty-six acute TBI patients were selected as study group and 30 healthy examinees at the same time were recruited as control group.The IGF-1 level was detected 1,3,5,7,14 d after TBI and the cognitive dysfunction was evaluated based on Montreal congnitive assessment (MoCA) score 6 months after the injury,and Pearson correlation was performed between IGF-1 level and MoCA score.Results There were 36 TBI patients (41.86％) with cognitive dysfunction,who were assessed by MoCA scale.The main deficits contained visuospatial and executive functioning,attention and calculation,language,abstraction and delayed recall.The serum IGF-1 level of TBI patients was significantly lower than that of the control group at all time points after TBI (P ＜ 0.05).The serum IGF-1s 1,3,5 d after TBI were significantly lower in the patients with cognitive dysfunction than in the patients with normal cognition (P ＜ 0.05).The IGF-1 level was positively correlated with the MoCA score at 1,3 and 5 d after TBI in study group (P ＜ 0.05).Conclusion The dynamic change of serum IGF-1 level in patients with acute TBI is closely related to cognitive function.The serum IGF-1 level in the early stage after TBI can be used to predict the cognitive function of the patients.
Keywords：craniocerebral traumaacuteinsulin-like growth factor-1cognitive dysfunction
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 241-244 )