Expression and its clinical significance of Moesin in glioma
Zhang Zhe
Yang Jian
Jiang Fuqiang
Lu Wei
Abstract：Objective To explore the expression of membrane structure extending spike protein (Moesin) in glioma and its relationship with clinical features and its role in clinical prognosis. Methods The clinical data and mRNA microarray data of 514 patients with gliomas obtained from the Cancer Gene Map ( TCGA ) database were collected and analyzed for expression of Moesin . The Kaplan-Meier survival curve was used to analyze the relationship between the expression of Moesin and survival of patients with glioma. The relationship between Moesin and age, sex and pathologic grade of glioma was further analyzed by multivariate analysis of variance. Results With the pathological grade of glioma increased, Moesin expression increased (P< 0.001). The expression of Moesin was significantly correlated with the overall survival and disease-free survival of patients with glioma. Patients with higher Moesin expression had shorter overall survival and disease-free survival (P<0.001). Conclusion Moesin may serve as a potential tumor diagnostic markers and an individual therapeutic target.
Keywords：gliomasmembrane structure extending spike proteintherapeutic targetoveral survivaldisease-free survival
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 201-204 )