Clinical characteristics and relevant risk factors of acromegaly combined with thyroid diseases

Gao Lu; Wu Xia; Guo Xiaopeng; Li Yilin; Zhang Shuo; Wang Qiang; Wang Zihao; Lian Wei; Wang Renzhi; Xing Bing

doi:10.11850/j.issn.1009-122X.2017.04.002

Abstract：Objective To explore the clinical characteristics and risk factors of acromegaly combined with thyroid diseases.Methods Ninety-three patients newly diagnosed with acromegaly were recruited according to the inclusion and exclusion criteria.All the patients underwent thyroid ultrasonography and were diagnosed with TI-RADS evaluation system.Multivariate linear regression analysis was used to detect the correlations between clinical data.Binary logistic regression analysis was used to identify risk factors.Results Seventy-two acromegalic patients (77.4％) complicated with thyroid diseases including 69 benign and 3 malignant were set as thyroid-disease group,and remaining 21 patients with normal thyroid were set as normal thyroid group.Multiple linear regression analysis showed that volume of thyroid was linearly correlated with growth hormone (GH) random value (P =0.002),growth hormone nadir value (P =0.005) and insulinlike growth factor (IGF-1) value (P =0.004).T3 level was linearly correlated with IGF-1 value (P ＜0.05).Thyroid-disease group had higher GH load than normal thyroid group (P ＜ 0.05).Multivariate logistic regression analysis showed that age was an independent risk factor for acromegaly combined with thyroid diseases (P =0.002).Conclusions Compared with the normal population,the risk for benign or malignant thyroid disease is significantly higher in acromegaly and age is an independent risk factor.The volume and function of thyroid are closely related to abnormally elevated growth hormone and IGF-1.Clinical doctors should make the early assessment and standardized diagnosis and treatment of concomitant diseases of acromegaly and pay morn attention to the endocrinological recovery after surgery.