Clinical and pathological analysis of idiopathic hypertrophic pachymeningitis
Wang Wei
Chen Xiaodong
Peng Dayun
Lai Xuwen
Zhou Yongmei
Cui Jing
Abstract：Objective To investigate the key points for pathological diagnosis of idiopathic hypertrophic pachymeningitis (IHP). Methods The clinical and imaging data of 3 patients with IHP undergoing surgery were analyzed retrospectively. The morphological characteristics were observed under light microscope. The 2 male and 1 females undergoing surgery presented common complaints of headache or lower back pain with lower extremity numbness and weakness. Results Imaging showed diffuse or nodular thickening of the dura. Microscopically, the thickening of the dura was associated with dense fibrosis and collagen deposition, accompanyed with a mixed inflammatory infiltrate composed mainly of plasma cells and small lymphocytes. Neutrophils can be seen in some cases. Immunohistochemistry showed fibrous tissue positive for SMA and MSA. The plasma cells were positive for CD38, CD138, EMA and IgG, but negative for IgG4. The CD45RO-positive T lymphocytes were markedly more than CD20-positive B lymphocytes. Conclusions IHP is rare and its accurate diagnosis depends on the comprehensive analysis of clinical history, imaging and pathological features.
Keywords：pachymeningitishypertrophicidiopathicpathologyclinicalimaging
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 60-62 )