Efficacy analysis of subthalamic nucleus deep brain stimulation for Parkinson's disease
Tao Yingqun
Wang Ying
Liang Guobiao
Xu Feng
Wen Liang
Li Zhiyong
Zhang Youqian
Gao Dandan
Li Xiaoming
Abstract：Objective To assess the clinical efficacy of subthalamic nucleus-deep brain stimulation ( STN-DBS ) for Parkinson's disease. Methods Clinical data of 32 Parkinson's disease patients undergoing STN-DBS were analyzed retrospectively. The unified Parkinson's disease rating scale (UPDRS), self-rating depression scale (SDS) and the symptom checklist (SCL-90) were scored for follow-up assessment, mental status questionnaire and analysis before and 3 months after surgery. Results After the opening of pulse generator, daily living activities and motor function in UPDRS of 32 patients were in the 'off' state and the average improvement rate was 51.7% and 60.9% respectively, while in the 'on' state, the average improvement rate was 21.4% and 22.3% respectively. There were 20 patients whose preoperative SDS scores were more than 50 points and whose seven factors in SCL-90 including depression, anxiety, somatization, interpersonal sensitivity, hostility, fear and paranoia were significantly higher than the Chinese norm (P<0.05). Comparing the postoperative depression, somatization, fear, anxiety and psychosis factor to preoperative, those showed a significant difference (P< 0.05), while interpersonal sensitivity, paranoia, hostility and obsession showed no significant difference (P> 0.05). Conclusions STN-DBS can not only improve motor function and daily living skills of Parkinson's disease patients, but also significantly improve mental status of patients with depressive disorder, therefore, being a safe and effective method.
Keywords：Parkinson diseasesubthalamic nucleusdeep brain stimulation
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 19-22 )