The expression and significance of CXCL12 and its receptor CXCR4 in children with adamantinomatous craniopharyngioma
Zhang Haili
Hu Wanning
Zhao Xiqing
Gong Jian
Abstract：Objective To explore the expression of CXCL12, CXCR4 and Ki-67 in children with adamantinomatous craniopharyngioma and their correlation with the recurrence and prognosis of tumor. Methods Samples of 45 child patients with adamantinomatous craniopharyngiomas were collected, including recurrent tumors in 27 and nonrecurrent tumors in 18. The expression of CXCL12, CXCR4 and Ki-67 mRNA and protein were detected by high-throughput microarray analysis, quantitative real-time PCR (qRT-PCR) and immunohistochemistry. Results The microarray results showed that the expressions of CXCL12 and CXCR4 genes were significantly increased in recurrent samples. The high level of CXCL12 and CXCR4 were significantly associated with recurrence (P < 0.05) and not associated with tumor size and gender (P > 0.05). There was positive correlation between CXCR4 and CXCL12 proteins (r = 0.74, P <0.01). A weak association was found between CXCR4 and Ki-67 proteins (r = 0.28, P = 0.06), while the expression of CXCL12 and Ki-67 proteins were not significantly correlated (r = 0.15, P = 0.32). Conclusion The high levels of CXCL12 and CXCR4 may be the tumor marker for evaluating the recurrence in children with adamantinomatous craniopharyngiomas.
Keywords：craniopharyngiomasadamantinomatousproteinCXCR4CXCL12Ki-67children
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 513-516 )