Clinical features, diagnosis and treatment of intracranial multifocal germ cell tumors
Fang Luxiong
Xu Shuxiang
Zhu Minghua
Qi Songtao
Abstract：Objective To summarize the clinical features of intracranial multifocal germ cell tumors and explore the reasonable therapeutic strategies. Methods Clinical data of 27 patients with intracranial multifocal germ cell tumor were analyzed retrospectively. There were 69 intracranial lesions in total, which was located mainly in the pineal region and sellar region. The largest lesion was located in pineal region in 15 patients, suprasellar region in 11 and frontal lobe in 1. Elevation of serum β-HCG was seen in 7 patients, elevation of AFP in 1 and elevation of both serum β-HCG and AFP in 1. The radiotherapy was performed on 24 patients including 8 undergoing chemotherapy. And 3 patients quit treatment. Results Among the 24 patients who received surgery, 3 patients who had finished radiotherapy were receiving chemotherapy and the examination showed that all the lesions disappeared. Nineteen patients were followed up for 6 months to 6.25 years with a mean period of 3.75 years. Death occurred in 1 patient, recurrence in 1 and no relapse in 17 patients who had normal lives. Two patients were lost to follow-up. Conclusions Intracranial multifocal germ cell tumors are composed predominantly of germinoma, which are considered to be resulted from the dissemination of tumors. Enhanced treatment including the whole CNS radiotherapy can achieve good prognosis.
Keywords：germinomaintracranialpineal regionsellar regionradiotherapydrug therapycombination
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 488-490 )