The mechanism of leptin, leptin receptor and STAT3 expressions in intracerebral hemorrhage from arteriovenous malformations rupture and their influences
Zhao Xiaoyong
Zhang Xiaoli
Wu Zhanfei
Abstract：Objective To investigate the changes in expressions of vascular susceptibility gene leptin, leptin receptor and signal transduction and transcriptional activation factor 3 (STAT3) in intracerebral hemorrhage from arteriovenous malformation (AVM) rupture and their effects. Methods Eighty patients with cerebral AVM were randomly divided into bleeding group (n = 40) and non-bleeding group (n = 40). The real-time quantitative PCR and Western blotting technique were used to detect leptin, leptin receptor and STAT3 expressions in cerebral AVM. Results The results from real-time quantitative PCR and Western blotting showed that there were significant differences in leptin, leptin receptor and STAT3 expressions between bleeding and non-bleeding groups, with a significant statistical significance (all P <0.01). Conclusions Studies at a level of molecular biology about the influences of leptin and leptin receptor and STAT3 on intracerebral hemorrhage due to AVM rupture play an important role in predicting and reducing the risk of intracerebral hemorrhage due to AVM rupture and in clinical diagnosis and treatment of the hemorrhage.
Keywords：intracranial arteriovenous malformationscerebral hemorrhageleptinleptin receptorsignal transduction and activation of transcription factor 3
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 466-468 )