Effects of gamma knife on the cognitive function of patients with medically intractable epilepsy
Liang Chuandong
Liu Na
Cao Hongxu
Wu Jiang
Kang Jinsheng
Guo Tao
Yue Xiangyong
Chen Xiaogang
Li Wenling
Zhao Wenqing
Abstract：Objective To explore the effects of gamma knife on the cognitive function of the patients with medically intractable epilepsy. Methods Clinical data of 41 patients with medically intractable epilepsy undergoing gamma knife treatment were analyzed retrospectively. Engel grade was used to assess the control situation of epileptic seizure. Raven's standard progressive matrices (SPM) score was applied to evaluate the cognitive function, and relative factors that might influence cognitive function were analyzed. Results Engel gradeⅠwas achieved in 3 patients after treatment, gradeⅡin 9, gradeⅢin 17 and gradeⅣin 12. Compared with the preoperation, the postoperative SPM score increased in 13 patients, decreased in 4 and unchanged in 24. The mean IQ score was 73.3± 18.9 at preoperation and 77.3±19.8 at postoperation, and significant difference was found between them (P<0.05). There were no significant differences in cognition between patients with temporal epilepsy and non-temporal epilepsy after treatment (P>0.05), while there were significant differences in cognition between patients of Engel gradeⅠtoⅢ and gradeⅣ (P<0.05). Conclusion Gamma knife can partially improve the cognitive function of the patients with medically intractable epilepsy, is a safe and effective treatment with a good application prospect.
Keywords：epilepsyneurobehavioral manifestationradiosurgery
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 300-302 )