Magnetic targeted microvascular embolization by paramagnetic nanoparticles
Wang Xiaopeng
Fu Xiangping
Li Anmin
Chang Jin
Liang Chao
Zhao Ming
Abstract：Objective To test the role of paramagnetic nanoparticles in embolizing microvascular embolization under the guidance of magnetic field. Methods The paramagnetic nanoparticles were synthesized with chitosan and ferrofluid Fe3O4. The condensation of particles under magnetic field was observed in mimicked microvascular in vitro. The intravenous injection of nanoparticles was executed in rats and an external magnetic field (0.5T) was placed across their brains, which were sampled and stained by Prussian blue iron staining to observe microvascular embolization under microscope. Results The manufactured paramagnetic nanoparticle solution was black without floccules or precipitation. The mean diameter of the nanoparticle was 15.3 nm under electron microscope. These paramagnetic nanoparticles deposited in the microvessels in vitro and vivo, and resulted in microvascular embolization. Conclusions It is feasible to perform microvascular embolization by magnetic targeted therapy with paramagnetic nanoparticles, which may become a new method for superficial tumors and cerebrovascular diseases.
Keywords：vascular embolizationnanotechnologymagnetic-targetedrats
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 274-276 )