Regulation of glioma invasion by Insulin-like Growth Factor Binding Protein 2 (IGFBP2) and its binding partner Ⅱp45
Abstract：Gene expression profiling studies with glioma tissues of different grades led us to the discovery that insulin-like growth factor binding protein 2 (IGFBP2) is overexpressed in the advanced stage of glioma-glioblastoma multiforme or GBM. Subsequent studies including tissue microarray analysis revealed the IGFBP2 overexpression is present in 80% of GBM and by far is the most frequent molecular event uniquely observed in GBM. Functional studies showed that IGFBP2 is an enhancer of glioma invasion. Using yeast two-hybrid technique, we have identified a novel gene Ⅱp45 that encodes a binding partner of IGFBP2. The function of Ⅱp45 is inhibition of invasion. Thus, our functional genomic studies have characterized IGFBP2 and Ⅱp45 as a pair ofinteracting proteins with opposing functions in glioma invasion regulation.
Keywords：gliomaGBMglioblastomeinsalin-like growth factor binding protein 2 (IGFBP2)Ⅱp45
Publication Date：2004-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 478-482 )