Advances in Coating Technologies for Extracorporeal Life Support Systems
GAO Tianyu
LIU Qindong
LIU Jia
WANG He
JIN Yu
LIU Jinping
Abstract：Extracorporeal life support(ECLS)is a critical therapeutic modality for managing patients with life-threat-ening conditions such as cardiogenic shock and acute respiratory distress syndrome(ARDS).However,its clinical application remains constrained by biocompatibility challenges at the blood-material interface.This review comprehensively examines recent advances in ECLS coating technologies,and systematically analyzies their molecular mechanisms and clinical implementation challenges.We critically evaluate the advantages and limitations of mainstream coating strategies,including heparinized coatings,phosphorylcholine-based polymers,and nitric oxide-releasing surfaces.Furthermore,we discuss emerging coating technologies,such as endothelial-mimicking coatings and novel ionic polymer composites.To date,only heparin and phosphorylcholine coat-ings have achieved widespread clinical adoption,while other coatings exhibit distinct limitations despite their potential benefits.Thus,most novel coating materials require further optimization through preclinical and clinical validation.Future research should prioritize the development of multifunctional composite coatings that integrate nanotechnology and biomimetic designs to en-hance long-term hemocompatibility and mitigate inflammatory responses in ECLS systems.
Keywords：coating technologyextracorporeal life supportextracorporeal membrane oxygenationextracorporeal circu-lationanticoagulationheparinphosphorylcholinecritical illness
Publication Date：2025-12-28
Online Publishing Date：2026-01-16(First online date of this platform, not the publication date of the document)
Pages：6( 543-548 )