The Dual Effect of Adsorption Technology in Cardiopulmonary Bypass:Inflammatory Regulation and Drug Clearance in Clinical Challenges
ZHANG Siyu
LI Xiaoning
MA Hongliang
Abstract：Systemic inflammatory response syndrome(SIRS)long with disruptions in pharmacokinetics(PK)and phar-macodynamics(PD)induced by extracorporeal circulation(ECC)represents a significant contributor to postoperative compli-cations following cardiac surgery.In recent years,blood adsorption technology has demonstrated considerable potential in im-proving postoperative outcomes by clearing inflammatory mediators and toxic substances.However,its unintended elimination of therapeutic drugs has sparked widespread debate.This review systematically examines the mechanisms of adsorption devices,summarizes their dynamic impacts on drug concentrations,and analyzes clinical challenges and controversies.This review aims to clarify the"double-edged sword"effects of adsorption technology,providing a theoretical foundation for individualized drug management in cardiac surgery,and advocating for a paradigm shift from"broad-spectrum inflammatory control"toward"preci-sion therapeutic strategies".
Keywords：adsorption technologyextracorporeal circulationdrug eliminationsystemic inflammatory response syn-dromepharmacokineticstherapeutic drug monitoring
Publication Date：2025-12-28
Online Publishing Date：2026-01-16(First online date of this platform, not the publication date of the document)
Pages：4( 540-542,562 )