Clinical Outcomes and Risk Factors of Extracorporeal Membrane Oxygenation for Circulatory Support in Pediatric Pa-tients:a Single-Center Experience of 52 Cases
XU Wanyu
HUANG Hongjuan
YUAN Hongliang
SHEN Weijia
XU Guiying
RONG Shuhan
WANG Hao
WU Songhua
LI Xin
ZHANG Wenting
WEI Tongxia
LIAO Jianyi
Abstract：Objective To investigate the clinical outcomes and influencing factors of extracorporeal membrane oxygen-ation(ECMO)support in pediatric patients with circulatory failure.Methods A retrospective analysis was performed on 52 children who received ECMO support for circulatory failure at the Children's Hospital of Soochow University between Decem-ber 2017 to May 2025.Patients were divided into survival and death groups according to hospital discharge outcomes.Baseline characteristics,ECMO management strategies,and complications were compared between the two groups,and long-term fol-low-up was conducted among survivors.Results The successful weaning rate from ECMO was 69.2%(36/52),the hospital sur-vival rate was 51.9%(27/52),and the one-year survival rate was 42.3%(22/52).The proportions of patients receiving extracor-poreal cardiopulmonary resuscitation(ECPR)and renal replacement therapy were significantly higher in the death group than in the survival group(56.0%vs.14.8%,P=0.005;76.0%vs.40.7%,P=0.022).Multivariate logistic regression identified ECPR as an independent risk factor for in-hospital mortality(OR=0.163,95%CI:0.038-0.703,P=0.015),while renal replacement therapy showed a trend toward an increased risk of death(P=0.068).During follow-up,primary disease-related problems were the lead-ing cause of long-term morbidity(33.3%),followed by neurological sequelae(25.9%)and moderate exercise intolerance(7.4%).Conclusion ECPR is an independent risk factor for poor outcomes in pediatric patients supported with ECMO,whereas the need for renal replacement therapy indicates critical illness and is associated with adverse prognosis.Primary disease exerts a sig-nificant impact on long-term outcomes,underscoring the importance of targeted management and structured long-term follow-up to improve overall prognosis.
Keywords：extracorporeal membrane oxygenationpediatriccirculatory failurecongenital heart diseasefulminant myocarditisextracorporeal cardiopulmonary resuscitation
Publication Date：2025-12-28
Online Publishing Date：2026-01-16(First online date of this platform, not the publication date of the document)
Pages：5( 504-508 )