Development of enoxaparin sodium-polycaprolactone sustained-release microspheres
Hu Xingyu
Zhang Pengfei
Zhao Gang
Cheng Guangcun
Abstract：Objective To prepare enoxaparin sodium-polycaprolactone(LMWH-PCL)sustained-release microspheres,observe their surface morphology,and test their physical properties,we aimed to provide a preparation method for the clinical application of low-molecular heparin sustained-release microspheres.Methods Microspheres were fabricated by the W/O/W method.The surface topological morphology of microsphere preparations was characterized using scanning electron microscopy(SEM),while the size distribution characteristics of particulate populations were quantitatively determined using a laser diffraction particle size analysis system.The drug loading and encapsulation rate of the drugs in the microspheres were determined using the measurement of anti-Xa factor potency method.Results Scanning electron microscopy and laser particle sizing showed that the larger the molecular weight of polycaprolactone,the more spherical the microsphere morphology,and the more homogeneous the particle size.However,the results of drug loading rate and encapsulation rate of enoxaparin sodium in microspheres determined by potency method were unsatisfactory.Conclusion LMWH-PCL microspheres could release the drug,which verified the feasibility of the microspheres for slow drug release.
Keywords：Enoxaparin sodiumPolycaprolactoneMicrospheresSustained release
Publication Date：2025-08-28
Online Publishing Date：2025-08-27(First online date of this platform, not the publication date of the document)
Pages：5( 361-365 )