Research on the role and mechanism of miR-29b-enriched exosomes in inhibiting post-myocardial infarction ventricular remodeling
Zheng Wei
Wang Xiaoming
Han Zhiwei
Zou Long
Fan Chenliang
Sun Hongda
Yuan Jianping
Abstract：Objective To investigate the role and underlying mechanisms of exosomes(EXOs)enriched with miR-29b in inhibiting post-myocardial infarction(MI)ventricular remodeling.Methods miR-29b-enriched EXOs were engineered via in vitro transfection and administered to MI-induced mice through tail vein injection.The experiment was divided into four groups:normal control,MI model,EXO-treated,and miR-29b-enriched EXO-treated.Cardiac function,ventricular remodeling,and related molecular mechanisms were assessed using echocardiography,histopathological staining,and Western blot analysis.Results Compared to the MI model group,miR-29b-enriched EXO treatment significant improved post-MI cardiac function,in the miR-29b-enriched EXO group.miR-29b overexpression in cardiac tissue correlated with downregulated collagen I and collagen III expression.Conclusion Tail vein injection of miR-29b-enriched EXOs effectively suppresses ventricular remodeling post-MI by targeting myocardial fibrosis.This study highlights the potential of miRNA-engineered exosomes as a novel therapeutic strategy for cardiovascular diseases.
Keywords：Acute myocardial infarctionExosomemiR-29bVentricular remodelingMyocardial fibrosis
Publication Date：2025-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 258-262,268 )