Association of urinary calprotectin levels with acute kidney injury during cardiopulmonary bypass:a observational study
Jia Bin
Luo Yong
Chen Jie
Fei Junjie
Chen Jian
Abstract：Objiective To evaluate the potential of urinary biomarker calprotectin in the early detection of acute kidney injury(AKI)after cardiopulmonary bypass(CPB)and to propose a novel diagnostic approach.Methods This study enrolled 126 patients who underwent CPB-assisted cardiac surgery at Chengdu Third People's Hospital in 2023.Urine samples were collected at four perioperative time points,and urinary calprotectin levels were quantified using enzyme-linked immunosorbent assay(ELISA).The correlation between urinary calprotectin levels and AKI was assessed.AKI diagnosis was made according to the 2012 KDIGO guidelines.Results The study included 126 patients,38 of whom developed AKI postoperatively.Urinary calprotectin levels exhibited significant dynamic changes during the perioperative period,with AKI patients showing markedly higher levels than non-AKI patients,particularly at the end of surgery.Multivariable regression analysis revealed a significant correlation between urinary calprotectin levels at the end of surgery and the occurrence of AKI.Conclusion Urinary calprotectin could serve as an early biomarker for AKI following CPB,and its elevation at the end of surgery could reliably predict the risk of AKI.Monitoring dynamic changes in urinary calprotectin levels may facilitate the early diagnosis and prompt intervention of AKI.
Keywords：Cardiopulmonary bypassCardiac surgeryAcute kidney injuryUrinary calprotectinBiomarker
Publication Date：2025-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 238-242 )