Microbial profile in patients undergoing extracorporeal membrane oxygenation:a retrospective cohort study
Chen Wu
Liu Gang
Wang Jing
Wang Jian
Wang Tianlong
Teng Yuan
Ji Bingyang
Abstract：Objective To retrospectively analyze the microbial distribution patterns in patients receiving extracorporeal membrane oxygenation(ECMO).Methods This single-center retrospective cohort study analyzed 95 patients with microbiologically confirmed infections during ECMO support at Fuwai Hospital from March 2017 to August 2022.Clinical data,pathogen profiles from specimens,infection biomarkers,ECMO parameters,and mortality outcomes were systematically evaluated.Results The cohort(mean age 51±14.4 years,62.1%male)predominantly received venoarterial ECMO(V-A ECMO:92/95).Respiratory specimens demonstrated the highest positivity rate(89/95,93.7%),followed by urinary(15/95,15.8%)and bloodstream infections(3/95,3.2%).Gram-negative bacilli(86 isolates)predominated,with Klebsiella pneumoniae(26.7%),Pseudomonas aeruginosa(22.1%),and multidrug-resistant Acinetobacter baumannii(18.6%)as leading pathogens.Gram-positive cocci(82 isolates)were primarily coagulase-negative staphylococci(34.1%),Staphylococcus aureus(29.3%),and Enterococcus spp.(19.5%).Fungal infections(64 isolates)featured Candida species(56.3%),filamentous fungi(23.4%),and Candida albicans(20.3%).Notably,A.baumannii infections correlated with 76%in-hospital mortality,filamentous fungi with 60%,and S.aureus with 53.8%.Conclusion During ECMO support,patients exhibit a significantly higher positivity rate in sputum specimens compared to other sample types.Patients receiving ECMO are critically ill with compromised immune function,frequently presenting with polymicrobial co-infections.
Keywords：Extracorporeal membrane oxygenationVeno-arterial extracorporeal membrane oxygenationPathogenic bacteriaNosocomial infection
Publication Date：2025-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 108-112 )