Prediction of serum NT-proBNP and sST2 for cardiovascular events in maintenance hemodialysis patients
Zhang Yinghui
Shen Jie
Wang Yanan
Guan Xuejing
Chen Sijun
Jiang Qian
Abstract：Objective To investigate the predictive significance of serum N-terminal B-type natriuretic peptide precursor(NT-proBNP)and soluble tumor suppressor protein 2(sST2)for the risk of major adverse cardiovascular events(MACE)in maintenance hemodialysis(MHD)patients.Methods From March 2022 to March 2023,118 patients with MHD for more than 3 months were selected in the Nephrology Department of Yangpu Hospital affiliated with Tongji University.Immunoassay was used to measure the levels of NT proBNP and sST2.The association of these biomarkers with 1-year MACE incidence rate was assessed.Clinical data were analyzed using SPSS version 26.0.Results MACE occurred in 20 patients during the study period.Serum NT-proBNP in MACE group[24214.50(6 299.75,35000.0)ng/L vs.4 462.0(2 289.25,9 715.0)ng/L,Z=-4.040,P<0.001],sST2 levels[7.30(5.38,20.33)μg/L vs.3.65(1.83,9.88)μg/L,Z=-2.622,P=0.009]were significantly higher than those in the non-MACE group.The incidence rate of MACE was significantly different between the high and low expression groups of sST2(log rank=14.857,P<0.001)or NT-proBNP(log rank=13.686,P<0.001).In multivariate analysis,the risk of MACE was significantly increased(P<0.05)when serum sST2≥14.10 μg/L(HR=9.703)or NT proBNP≥5 410.51 ng/L(HR=12.200～38.668).The efficacy of sST2 combined with NT-proBNP in predicting the risk of MACE in MHD patients(0.876)was higher than that of the two indicators alone(Z=-2.911,P=0.004;Z=2.065,P=0.039).Conclusion Serum sST2 and NT-proBNPs are valuable for predicting the one-year risk of MACE in MHD patients,with their combined use offering superior predictive performance.
Keywords：N-terminal B-type brain natriuretic peptide precursorSoluble suppression of tumorigenesis-2Maintenance hemodialysisMajor adverse cardiovascular events
Publication Date：2025-02-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 44-51 )