Clinical study on hemoperfusion for early cytokine storm following Sun's procedure
Li Xiangmin
Lv Shanshan
He Qing
Feng Bo
Yan Xiaoli
Zheng Yun
Zhang Chunlei
Ma Jipeng
Zhao Rong
Jin Zhenxiao
Zhang Ping
Abstract：Objective To investigate the clinical efficacy of hemoperfusion(HP)in the treatment of early postoperative cytokine storm(CS)after Sun's procedure.Methods The data of 54 patients with acute type A aortic dissection(AAD)who developed CS within 24 h post Sun's procedure were retrospectively collected from July 2021 to July 2023 in the Department of Cardiovascular Surgery of the First Affiliated Hospital of Air Force Medical University.The patients were divided into hemoperfusion group(27 cases)and control group(27 cases)according to whether they were treated with HP,and the prognosis of the two groups were compared.Results There were no significant differences in baseline characteristics between the two groups.HP significantly reduced IL-6 levels(days 1,2,3,4,7;all P<0.001)and CRP levels(day1,P=0.034;day 2,P=0.002;day 3,P=0.001;day 4,P=0.003;day 7,P=0.003).Compared to the control group,the mechanical ventilation time(P<0.001),ICU stay(P=0.013)and postoperative hospital stay(P=0.0212)were shorter in the hemoperfusion group.However,there were no statistically significant differences in postoperative delirium(P=0.526),reintubation(P>0.999),CRRT(P>0.999),pulmonary infection(P=0.728),and mortality(P>0.999)between the groups.Conclusion HP effectively reduces the levels IL-6 and CRP levels,shortens mechanical ventilation time,ICU stay and postoperative hospital stay in patients with early CS following Sun's procedure.However,it does not improve the incidence of postoperative delirium,pulmonary infection,death,or mortality,nor does it reduce the need for reintubation or CRRT.
Keywords：HemoperfusionExtracorporeal circulationSun's procedureModerate hypothermic circulation arrestType A aortic dissectionCytokine stormPerioperative period
Publication Date：2025-02-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 36-39,57 )