Evaluation of pathogens and drug resistance of nosocomial infection during extracorporeal membrane oxygenation support
Ren Yucheng
Wang Rui
Tong Yaowei
Zhou Wangtao
Xu Tianwei
Li Ying
Song Yunlin
Abstract：Objective To investigate the distribution and drug resistance of pathogens in nosocomial infection(NIs)during extracorporeal membrane oxygenation(ECMO)support,and to providing evidence for the rational use of antibiotics.Methods The clinical indexes and drug sensitivity test results of patients with nosocomial infection supported by ECMO were collected retrospectively from June 2018 to December 2023 in the Intensive Medicine Center of the First Affiliated Hospital of Xinjiang Medical University.The distribution trend of pathogens was analyzed.The bacteria were identified by VIETEK-Jr automatic bacterial identification and drug sensitivity analysis system,and the drug sensitivity test was carried out by disk diffusion method.Results Among 68 ECMO patients,40(58.82%)experienced 51 times episodes of NIs,with an incidence of 75%and an infection density of 71.56 ‰(/1000 ECMO days).The predominant infection site was the lower respiratory tract(45 cases,88.24%).51 strains were isolated,mainly Gram-negative bacteria(38 strains,74.51%),17 multidrug resistant strains(33.33%),of which 10 strains of Acinetobacter baumannii were resistant to cephalosporin and meropenem.The drug resistance rate of tegacycline(11.1%)and cefoperazone/sulbactam(30%)are lower.The fungal infection showed a high incidence(19.61%).Conclusion Gram-negative bacilli,particularly MDR Acinetobacter baumannii are the main pathogens of NI during ECMO support.Reasonable selection of antibiotics may provide clinical benefits in managing infections.
Keywords：Extracorporeal membrane oxygenationNosocomial infectionEtiologyDrug resistance
Publication Date：2025-02-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 29-35 )