Correlation between vasoactive-inotropic score and mechanical ventilation duration and hospital stay in infants after congenital heart disease surgery
Bao Rongxing
Jiang Chahua
Gu Xiaolin
Liu Qi
Zhong Xing
Zhang Chongjian
Abstract：Objective To investigate the correlation between vasoactive-inotropic score (VIS) and in-hospital prognosis in infants after congenital heart disease surgery. Methods This retrospective study examined 230 infants with congenital heart disease underwent cardiac surgery at Guangdong Provincial People's Hospital from January 2019 to April 2019.The infants were divided into three groups based on the maximum VIS within the first 24 hours after surgery:unused group (VIS=0) (n=68),low-dose group (0<VIS≤5) (n=130),and high-dose group (VIS>5) (n=32). By establishing univariate and multivariate linear regression models,the association between VIS and mechanical ventilation duration,ICU stay,and postoperative hospital stay was evaluated. Results VIS was included in the multifactor linear regression model as a continuous variable,and after adjusting for correlated factors,an increase of 1 point in VIS was associated with an increase of 5.1 hours in mechanical ventilation (P<0.001),6.2 hours for intensive care unit stay(P=0.014),and 0.3 days for postoperative hospital stay (P=0.011).Including VIS groups in the multifactor linear regression model,the low-dose group exhibited increases of 34.2 hours in mechanical ventilation (P=0.015),64.0 hours for ICU stay (P=0.006),and 2.5 days for postoperative hospital stay (P=0.013) compared to the unused group after adjusting for relevant factors.The high-dose group experienced a lengthening of mechanical ventilation duration of 81.3 hours (P<0.001),ICU stay of 203.5 hours (P<0.001),and postoperative hospital stay for 8.0 days (P<0.001). Conclusions The duration of ICU stay,mechanical ventilation and postoperative hospital stay were correspondingly longer in infants with high VIS after cardiovascular surgery.
Keywords：Congenital heart diseaseInfantsVasoactive-inotrope scorePrognosisCardiopulmonary bypass
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 382-386,436 )