The effect of two long-term cardioplegia on myocardial protection during adult cardiac surgery with cardiopulmonary bypass
Li Zilin
Hu Jing
Duan Xujie
Li Mengyan
Jin Zhenxiao
Chen Tao
Abstract：Objective Retrospective comparison was conducted to evaluate the myocardial protective effects of del Nido solution and HTK solution in adult cardiopulmonary bypass cardiac surgery. Methods This study included 105 adult cardiac surgeries under extracorporeal circulation at the First Affiliated Hospital of Air Force Military Medical University from February 2022 to February 2023. The patients were divided into two groups based on the different myocardial protective fluids used:the del Nido (DN) group (55 cases) and the HTK group (50 cases). Clinical data related to patients and clinical indicators related to specific time points in perioperative period were evaluated. Results There was no statistical difference between the two groups in terms of extracorporeal circulation time,aortic occlusion time,and intraoperative urine volume (P>0.05). There was also no significant difference in left ventricular ejection fraction and left ventricular end-diastolic internal diameter (P>0.05). There was no statistical difference between the two groups in the blood test indexes of B-type natriuretic peptide (BNP),alanine transaminase (ALT),aspartate transaminase (AST),total bilirubin,creatinine,urea and lactic acid (Lac) (P>0.05). The DN group showed significantly lower myocardial perfusion and ultrafiltration volume compared to the HTK group (P<0.01). The DN group had more perfusion times than in the HTK group. Conclusion In adult cardiac surgery,del Nido solution exhibits excellent myocardial protective effects comparable to HTK solution.
Keywords：Del Nido cardioplegiaHTK cardioplegiaMyocardial protectionCardiopulmonary bypassCardiac surgery
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 360-364 )