The function of activated clotting time and activated partial thromboplastin time during extracorporeal membrane oxygenation in adults
Yin Xiaoxue
Liu Delin
Liu Yuan
Wang Minna
Liu Wei
Cheng Li
Zhang Qifeng
Ye Gang
Abstract：Objective Activated clotting time (ACT) has been the preferred monitoring index in extracorporeal membrane oxygenation (ECMO) patients for long. This retrospective study sought to evaluate the relationship between activated clotting time (ACT) and activated partial thromboplastin time (APTT) when they were used to monitor anticoagulation in patients undergoing extracorporeal membrane oxygenation (ECMO). Methods Patients administered with heparin during ECMO were included in this study. The primary endpoint was the relationship between paired ACT and APTT samples. Results Twenty-two patients who met the criteria for the study were included. Pearson analysis found weak correlation between ACT and APTT (r = 0.114, P = 0.003), and weak correlation between ACT and APTT was also founded in patients who benefited from venovenous ECMO (r = 0. 229, P = 0. 001). The levels of APTT (51.1±27.5 s) and ACT (196.1±35.7 s) in V-V ECMO group were different from those in V-A ECMO group (46.1±27.7 s for APTT and 205.4±33.1 s for ACT, respectively) with a statistical difference in ACT (P = 0.013). Compared with survivours, platelet count declined significantly (P ＜0.001) in nonsurvivors. Conclusion There was a weak correlation between ACT and APTT in patients supported with ECMO. The coagulation indices of different ECMO modes were different. Platelet count declined significantly during the treatment of ECMO in critical patients and was related to their prognosis.
Keywords：Extracorporeal membrane oxygenationActivated partial thromboplastin timeActivated clotting timeAnticoagulationPlatelet
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 18-21 )