Effects of penehyclidine hydrochloride on systemic inflammatory reaction in pa-tients undergoing cardiac surgery with cardiopulmonary bypass

Li Bi-xi; Zhu Shui-bo; Yin Gui-lin; Zhang Xiao-ming; Cheng Wang-sheng; Cheng Da-xin; Tao Jun

doi:10.13498/j.cnki.chin.j.ecc.2016.04.08

Abstract：[ Abstract]:Objective To investigate effects of penehyclidine hydrochloride ( PHC) on systemic inflammatory reaction in pa?tients undergoing cardiac surgery with cardiopulmonary bypass ( CPB) . Methods Forty patients undergoing cardiac surgery with car?diopulmonary bypass were enrolled in the study. All patients were randomly divided into trial group and control group ( twenty in each group). Patients in trial groupreceived an intravenous injection of 0.03 mg/kg PHC before anesthesia induction and those in control group were given the same volume of normal saline. Blood samples were collected at the following time points:before anesthesia induc?tion ( T0) , the end of the operation ( T1) , 6 hours ( T2) , 12 hours ( T3) and 24 hours postoperatively ( T4) for the measurement of IL-8, TNFα and NF-κB. The outcomes included duration of intubation ( DOI) , length of intensive care unit stay ( LOI) and length of hospital stay after the surgery ( LOH) . Results The plasma levels of IL-8 and TNFα increased significantly from T1 to T4 in both groups, and those in trial group were statistical lower than control group from T1 to T4 ( P<0.05). The plasma level of NF-κB in?creased significantly from T1 to T4 in both groups, and those in trial group were lower than control group from T1 to T4 ( P<0.05). The DOI, LOI and LOH in trial groupwere shorter than control group, but there were no statistically significant between two groups ( P>0.05) . Conclusion PHC inhibits systemic inflammatory response in patients undergoing cardiopulmonary bypass, and its mecha?nisms is relevant to the regulation of NF-κB signal way on the production of proinflammatory cytokinesas,like IL-8 and TNFα.