Three preservation solutions for cold storage of heart allograft:a systematic re-view and meta analysis
Li Yong-nan
Guo Sha-sha
Liu Gang
Yuan Yuan
Ji Bing-yang
Zheng Zhe
Wang Wei
Abstract：Objective Organ preservation solution has been designed to attenuate the detrimental effects during ischemic peri?od. The aim of this study is to systematically evaluate the evidence comparing preservation solutions for heart preservation. Methods Studies were searched in PubMed, Embase, the Cochrane Library, the Transplant Library and the International Clinical Trials Registry Platform. The primary outcomes were patient survival and donor heart dysfunction. Secondary outcomes were in-hospital mortality and enzyme gene expression. Results UW was associated with a significantly improved survival at 30 days and 90 days ( HR=1.16, 95%CI=1.11-1.22, P<0.00001;RD=0.03, 95% CI=0.01-0.05, P =0.002), compared with Celsior. Heart allografts preserved with UW exhibited less ischemic necrosis than those preserved with Celsior ( RD=-0.07, 95% CI=-0.08--0.05, P<0.00001) . UW was associated with increased survival compared with HTK. No significant difference was observed in donor heart dysfunction and in-hospi?tal mortality outcomes between HTK andCelsior solutions. Conclusion During cold static storage preservation, this study suggests that UW solution has superior clinical outcomes for heart transplantation compared with the other two organ preservation solutions. Besides, the protective effect of Celsior solution is similar to HTK solution on donor heart preservation.
Keywords：Heart transplantationOrgan preservationOrgan preservation solutionSystematic review
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 154-160 )