The association between the early neutrophil-to-lymphocyte ratio and outcome from extracorporeal membrane oxygenation support in postcardiotomy patients:a retrospective observational study
Li Cheng-long
Wang Hong
Liu Ya-zhou
Liu Nan
Jia Ming
Hou Xiao-tong
Abstract：Objective The neutrophil-to-lymphocyte ratio (NLR) is a biological marker that partly reflects the severity of systemic inflammation. The objective of this study was to assess the association between NLR and outcome from extracorporeal mem?brane oxygenation ( ECMO) support in postcardiotomy cardiogenic shock ( PCS) patients. Methods We performed a retrospective ob?servational study of 69 postcardiotomy patients with ECMO supportfrom January 2011 to December 2012. Patients with ECMO support duration less than 48 hours were excluded. The NLRs before ECMO support, on the day starting ECMO support, 1st day and 2nd day after ECMO support were analyzed.Results Fifty two (75.4%) patients successfully weaned from ECMO, 33 discharged. The survival rate after ECMO weaning was 63.5% and the total in-hospital survival rate was 47.8%. NLR of all patients elevated significantly after ECMO commenced.NLR in survival group were higher than non-survival group on 1st(18.6±10.8 vs 13.4±7.3, P =0.020) and 2nd (21.1±11.8 vs 15.2±7.2, P=0.008) day after ECMO support. Sixty nine patient were divided into three tertiles (T1, T2, and T3) by NLR on 1st after ECMO support. The in-hospital survival rate in T1 (7.8±1.6, mean NLR), T2(13.4±1.9,mean NLR), and T3(26. 6±8.7, mean NLR) was separately 30.4%, 47.8%, and 65.2% ( P =0.019). The survival rate after ECMO weaning was separately 50.0%, 57.9%, and 78.9% in T1, T2, and T3. Conclusion The survivals from ECMO support in PCS patients tend to have higher NLR in the early phase and may suffer from comparatively more intensive systemic inflammation. More clinical and experimental re?search should be conducted to illustrate the mechanisms of systemic inflammation during ECMO support.
Keywords：Cardiac Surgical ProceduresExtracorporeal Membrane OxygenationInflammation
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 132-136 )