Performance of a wearable artificial cardiopulmonary support device in a sheep model
Liu yang
Jin Zhen-xiao
Dong Xiao-chao
Wei Xu-feng
Yang Jian
Cheng Liang
Yu Shi-qiang
Abstract：Objective To evaluate the performance of a wearable artificial cardiopulmonary support device in vivo . Methods Heparin-coating hollow fiber and axial pump were used to setup a wearable artificial cardiopulmonary support device. Six 40-kg sheepwere used in the study. The left anterolateral thoracotomy were performed after general anesthesia. Then the veno-arterial connectionswere setup with cannulation in the right atrium and descending aorta. The saturation, partial oxygen pressure and partial carbon dioxidepressure of the inlet and outlet were measured, and oxygen transfer rate was calculated before operating devices and then every 2 hoursat 4.0L/ min for 12 hours. The plasma free hemoglobin and platelet activation were evaluated every 2 hours as well. Results The satu?ration of outlet was stable at over 98% during the study. The plasma free hemoglobin was lower than 20mg/ dL and the platelet activationwas lower than 8% over 12 hours. Conclusions The wearable artificial cardiopulmonary support device with heparin-coating hollow fi?ber and axial pump conducted the reliable performance in vivo.
Keywords：In vivoOxygen transfer rateBiocompatibilityWearableExtracorporeal membrane oxygenation
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 119-122 )