Comparison of the myocardial protective effect of minimal cardioplegia vs heart-beating in patients undergoing coronary artery bypass grafting with cardiopul-monary bypass
Chen Xiang-zhou
Liu Mei
Xiao Ying-bin
Chen Jin-jin
Chen Bai-cheng
Abstract：[ Abstract]:Objective To investigate the difference in the myocardial protective effect between the minimal cardioplegia and heart-beating in patients undergoing coronary artery bypass graft ( CABG) with cardiopulmonary bypass ( CPB) . Methods According to the different ways of myocardial protection, 40 patients in coronary artery disease undergoing CABG with CPB were included and ran?domized equally into two groups:experiment ( E) group and control ( C) group. E group we chose minimal cardioplegia with hyperpo?tassemia ( potassium 20 mmol/L) as the antegrade cardioplegia after aortic cross clamping, C group we chose conventional CPB with beating heart. The concentrations of potassium, hematocrit ( Hct) , lactate ( Lac) from the arterial blood gas and plasma levels of cardi?ac Troponin I ( cTnI) , creatine kinase MB ( CKMB) were compared among two groups at following time point:preoperation( T0) , 30 min after CPB ( T1) , end of CPB ( T2) , 6 h ( T3) ,12 h ( T4) ,24 h ( T5) and 48 h ( T6) after surgery. Preoperative general situation and counts of graft, time of CPB, operation, mechanical ventilation and ICU stay were also collected. Results There was no hospital death in either group. The time of CPB and operation in E group were obviously longer than C group ( P<0.05);the concentrations of potassium in E group were significant higher than C group in T1 and T2( P<0.01);plasma levels of CKMB and cTnI were significant higher than preoperation form T1 to T6 in two groups( P<0.01or P<0.05);plasma levels of CKMB and cTnI in E group were higher than C group, but there were not statistical difference between two groups form T1 to T6 ( P>0.05);there was no significant difference in the concentration of Hct, Lac and preoperative general situation and counts of graft, time of mechanical ventilation and ICU staybetween two groups ( P>0.05). Conclusion The minicardioplegia can provide comparative myocardial protective effect as conven?tional CPB with beating heart, and minicardioplegia can be used in patients undergoing CABG with CPB safely.
Keywords：Coronary artery bypass graftCardiopulmonary bypassMyocardial protectionCardioplegia solution
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 94-98 )