To investigate the relationship between deep hypothermic in plasma IL-6 dy-namic change and resuscitation phase delay loop patients

Liu chang; Xue Yunxing; Xu Zhenjun; Wang Dongjin

doi:10.13498/j.cnki.chin.j.ecc.2015.01.06

Abstract：Objective To observe deep hypothermia during extracorporeal circulation ( ECC) in the cardiac surgery,including deep hypothermic circulatory arrest (DHCA) subgroup and DHCA with selective cerebral perfusion (DHCA+ASCP) subgroup. Meth?ods 24 cases of patients with DHCA operation, respectively in pre- ECC, pre-DHCA, post-DHCA, 24 hours and 48 hours of post-operation. Group A as wakeup during the 24 hours post operation and Group B as delayed recovery more than 24 hours. We grouped all cases into Group A as DHCA only and Group B as DHCA with ASCP. Results Two cases died in all patients, the others were cured. The concentration of IL-6 at different time points after ECC than before ECC has a rising trend, but the difference was not signifi?cant ( P>0.05) . IL-6 plasma levels with ECC were gradually increased until it reached a peak after DHCA, until after 48 h showed a gradual downward trend. The serum levels of IL-6 were positive correlation with the time of ECC, aortic clamping ( ACC) and DHCA. The results of subgroups showed that the IL-6 of Group B was increasing more obviously than Group A ( P<0.05).The level of IL-6 in Group C in the time point of 24 hours post-operation was increasing more obviously than Group D, but the difference was not statistically significant ( P>0.05) . Conclusion Deep hypothermic ECC can cause systemic inflammatory response syndrome occurred;DHCA+AS?CP to reduce the inflammatory reaction in the process of role than the simple application of DHCA to the superior;The rise in plasma IL-6 levels increase the inflammatory response and post-operative delayed recovery exist between certain correlation;Length of ECC, ACC and DHCA time influence the plasma IL-6 release, may affect the post-operative patients with fluid resuscitation and inflammatory reac?tion degree. Take effective anti-inflammatory treatment may benefit to patients with more 48 hours after operation.