Effects of different partial pressure of oxygen during heart reperfusion on myo-cardial injury in patients with heart valve replacement
Li Bi-xi
Song Xiao-yang
Wang Wei
Zhang Yan
Cheng Wang-sheng
Cheng Da-xin
Tao Jun
Abstract：Objective To approach the effects of different partial pressure of oxygen during reperfusion on myocardial injury and early postoperative outcomes of patients with heart valve replacement. Methods 30 patients with rheumatic heart disease undergo-ing heart valve replacement surgery were randomized equally into two groups. The patients in group A received controlled partial pres-sure of oxygen approximately 200 mmHg, but it was instead of 400 mmHg in group B by adjusting oxygen concentration. Blood samples were collected via the radial artery at the time of before the surgery ( T0) , before aortic declamping ( T1) , 10 min ( T2) and 30 min ( T3) after release of the aortic crossclamp, 6 h ( T4) and 24 h ( T5) after the surgery for MB isoenzyme of creatine kinase ( CKMB) and cardiac troponin T ( cTnT) monitoring in both groups. The outcomes of patients included duration of intubation ( DOI) , length of intensive care unit stay ( LOI) and length of hospital stay after the surgery ( LOH) were also recorded. Results Compared to T0, both the concentrations of CKMB and cTnT were increased from T1 to T4 and reached the tops at T4 in two groups, and those at T5 were de-creased but only the concentration of CKMB near to T0. The serum CKMB level in group A was significant lower than in group B from T1 to T5, and the level of cTnT in group A was obviously lower than in group B from T2 to T5. The DOI, LOI and LOH in group A were shorter in group B, but there was not statistically significant between two groups. Conclusion Arrest heart reperfused by oxygen-ated blood with higher partial pressure of oxygen can result in significant increase of serum marker of myocardial injury, but would not affect early postoperative outcomes of patients with heart valve replacement.
Keywords：Extracorporeal circulationHeart valve replacementIschemia-reperfusion injuryPartial pressure of oxygenMB isoenzyme of creatine kinaseCardiac troponin TOutcome
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 169-173,192 )