The influence of HTK cardioplegia solution on the plasma osmotic pressure of pa-tients underwent coronary artery bypass grafting with extracorporeal circulation
Zhang Tao
Gao Chang-qing
Wang Jia-li
LI Jia-chun
Luo Jin
Ma Lan
Wen Yu
Xiao Cang-song
Wang Rong
Abstract：Objective To observe the influence of histidine-tryptophane-ketoglutarate ( HTK) cardioplegia solution on the plasma osmotic pressure of patients underwent coronary artery bypass grafting with extracorporeal circulation ( ECC) . Methods From January 2013 to March 2013, total 68 patients ( 55 males and 13 females) underwent coronary artery bypass grafting with ECC in our department. The age of these patients was 39-81 years old, and body weight was 50-99 kg. Routinely mild hypothermia ECC was ap-plied. 1500-3000 mL 4℃ HTK solution was perfused by the pump for myocardial preservation. The arterial blood samples of all pa-tients were taken to measure the concentration of serum sodium and the plasma osmotic pressure at these time points: before ECC ( T1) , before administration of HTK solution ( T2) , after administration of HTK solution ( T3) , 30 min after ECC beginning ( T4) , ECC ending ( T5) , aortic cannula removing ( T6) and patient leaving operating room ( T7) . Results A total of 68 patients were in-cluded in the study. All patients were normo-natremic at start of surgery. All patients developed hyponatremia after administration of HTK solution with a significant drop of serum sodium of 15 mmol/L ( P<0.01) . Meanwhile, the plasma osmotic pressure dropped sig-nificantly after administration of HTK solution ( P<0.01) . Both the serum sodium and the plasma osmotic pressure didn't reverse to the basic level ( T1) until patients leaved operating room ( T7) . Conclusion Both acute hyponatremia and low plasma osmotic pressure could occur during cardioplegia perfusion with HTK solution in coronary artery bypass grafting with ECC, and different strategy of ECC should be applied in this situation.
Keywords：Extracorporeal circulationHistidine-tryptophane-ketoglutarate solutionHyponatremiaPlasma osmotic pres-sure
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 156-158,151 )