The Value of Dual-Energy CT Quantitative Parameters in Predicting PD-L1 Expression in Patients with Non-Small Cell Lung Cancer

XIAO Xinen

doi:10.3969/j.issn.1672-7185.2026.02.012

Abstract：Objective To explore the value of dual-energy CT quantitative parameters in predicting programmed cell death ligand 1(PD-L1)expression in patients with non-small cell lung cancer.Methods The clinical data of 100 patients with non-small cell lung cancer admitted to Gutian County Hospital from August 2020 to August 2023 were retrospectively collected.The positive rate of PD-L1 was detected,and the patients were divided into a positive group(n=43)and a negative group(n=57)according to the test results.All patients were examined by dual-energy CT,and the iodine concentration(IC),effective atomic number(Zeff),and standardized iodine concentration(NIC)of the patients in the arterial phase and venous phase were measured and recorded.Multivariate logistic regression analysis and ROC curve analysis were used to analyze the predictive value of indicators for positive PD-L1 expression.Results The IC,Zeff and NIC values of the positive group were lower than those of the negative group in the arterial phase and venous phase(P<0.05).The values of IC,Zeff and NIC in arterial phase and venous phase were the predictive factors of PD-L1 positive expression in patients with non-small cell lung cancer(P<0.05).ROC curve analysis showed that the AUC of IC,Zeff and NIC values in arterial phase and venous phase to predict the positive expression of PD-L1 in patients with non-small cell lung cancer were 0.984 and 0.956 respectively.Conclusion The quantitative parameters of dual-energy CT have a good predictive value for the positive expression of PD-L1 in patients with non-small cell lung cancer,which is recommended for clinical use.