Retrospective Analysis of 328 Cases of Adverse Drug Reactions in A Hospital

XU Meifeng; CHEN Jianfeng

doi:10.3969/j.issn.1672-7185.2025.07.006

Abstract：Objective To summarize and generalize the occurrence patterns of adverse drug reaction(ADR),in order to provide reference for subsequent drug safety.Methods A retrospective analysis was performed on 328 ADR cases reported in Quanzhou Orthopedic-Traumatological Hospital from January 2022 to December 2023.The basic information,route of administration,types of drugs,involved organs/systems and clinical manifestations of ADR patients were analyzed.Results Among 328 ADR reports,there were 259 cases(78.96%)of general ADRs,62 cases(18.90%)of new general ADRs,4 cases(1.22%)of severe ADRs,and 3 cases(0.91%)of new severe ADRs.Among 328 ADR patients,there were 125 males(38.11%)and 203 females(61.89%).The probability of ADR in females was significantly higher than that in males.Among the patients with ADR,the highest proportion was observed in the 61～70 years(65 cases,19.82%)and 71～80 years(65 cases,19.82%)age groups.Among 328 ADR reports,the most frequent administration route was intravenous infusion(248 cases,75.61%),followed by oral administration(37 cases,11.28%).Antimicrobial agents accounted for the highest number of ADR-related drugs(124 cases,37.80%),followed by traditional Chinese medicine injections(42 cases,12.80%).Skin and its appendages were the most frequently involved organs/systems(103 cases,31.40%),followed by nervous system(51 cases,15.55%)and blood system(51 cases,15.55%).Conclusion The occurrence of ADR is associated with a variety of factors,among which antimicrobial agents and intravenous administration routes are the main factors leading to adverse reactions in patients.It is suggested that hospitals strengthen control to ensure drug safety.