The Therapeutic Effect of Danhuang Tongmai Capsules Combined with Atorvastatin on Carotid Plaques in Hypertensive Patients

ZHAO Qingling

doi:10.3969/j.issn.1672-7185.2025.04.011

Abstract：Objective To explore the therapeutic effect of danhuang tongmai capsules combined with atorvastatin on carotid plaques in hypertensive patients.Methods A total of 400 hypertensive patients with carotid plaques admitted to the Third People's Hospital of Xintai from December 2020 to November 2022 were randomly divided into an experimental group and a control group,with 200 cases in each group.All participants received a conventional treatment regimen after enrollment.Additionally,the experimental group received danhuang tongmai capsules combined with atorvastatin,while the control group was treated with atorvastatin alone.The changes in lipid levels and two-dimensional parameters of target plaques before and after treatment were compared,and a one-year follow-up was conducted to record the incidence of cerebrovascular diseases in both groups.Results After treatment,the total cholesterol,triacylglycerol,low density lipoprotein cholesterol,plaque thickness,plaque area,and intima-media thickness significantly decreased in both groups,with the experimental group showing lower values than the control group(P<0.05).But high-density lipoprotein cholesterol significantly increased in both groups,with the experimental group showing higher values than the control group(P<0.05).Follow-up results indicated that the incidence of cardiovascular diseases in the experimental group was significantly lower than that in the control group(P<0.05).Conclusion For hypertensive patients with carotid plaques,treatment with danhuang tongmai capsules combined with atorvastatin could effectively reduces lipid levels,inhibits the progression of carotid atherosclerotic plaques,and improves prognosis.