Comparison of the Application of Propofol Combined with Different Concentrations of Dezocine in the Treatment of Polyps under Painless Colonoscopy

ZHU Minglong

doi:10.3969/j.issn.1672-7185.2024.11.010

Abstract：Objective To compare the application effect of propofol combined with different concentrations of diazoxide in the treatment of polyp under painless colonoscopy.Methods A total of 100 colon polyp patients underwent painless colonoscopy polypectomy admitted to Wuhan Central Hospital of the Third Engineering Bureau of China Construction from May 2018 to December 2023 were selected for the study,and were randomly divided into 31 cases in the low concentration group,35 cases in the medium concentration group and 34 cases in the high concentration group.The 0.05 mg/kg,0.1 mg/kg,0.2 mg/kg dizocin was diluted with saline to 5 mL for intravenous injection,followed by intravenous pumping of 2.0 mg/kg propofol,and intraoperative pumping of 3～5 mL/(kg·h)was maintained.The patients'hemodynamics and EEG bispectral index(BIS)values were monitored,and the propofol dosage,postoperative awakening time and complications were recorded.Results Heart rate(HR),mean artery pressure(MAP),saturation of peripheral oxygen(SpO2),and BIS values were significantly changed in the three groups(P<0.05).The fluctuation in the low concentration group was more obvious than those of the medium concentration group and the high concentration group(P<0.05).The HR and SpO2 among the three groups showed no significant difference(P>0.05).The BIS values in the low concentration group and the high concentration group significantly decreased more than those of the medium concentration group(P<0.05).Compared with the low concentration group,the propofol dosage in the medium concentration and high-concentration groups decreased significantly(P<0.05),and the high concentration group was less than the medium concentration group(P<0.05).Comparison of postoperative awakening time among the three groups showed no significant difference(P>0.05).The total complication rate was 29.03%in the low-concentration group,28.57%in the medium concentration group,and 26.47%in the high concentration group,and the difference was not significant(P>0.05).Conclusion Propofol combined with 0.1 mg/kg diazoxide for painless colonoscopy polypectomy is a safety-effective anesthetic strategy.