Effect Analysis of Edaravone Combined with Sodium Valproate in the Treatment of Post-stroke Epilepsy

WANG Anna; XIANG Aixiang

doi:10.3969/j.issn.1672-7185.2024.09.003

Abstract：Objective To explore the efficacy of edaravone combined with sodium valproate in the treatment of post-stroke epilepsy.Methods A total of 80 patients with post-stroke epilepsy admitted to Jiaozhou Hospital,Dongfang Hospital Affiliated to Tongji University from October 2019 to October 2023 were selected as the study subjects.They were randomly divided into a control group and an observation group,with 40 cases in each group.All cases received routine treatment.On this basis,the control group received sodium valproate treatment,while the observation group received a combination of edaravone and sodium valproate treatment.Compare the therapeutic effects,incidence of adverse drug reactions,the levels of serum inflammatory factors and neuron specific enolase before and after treatment,as well as the seizure situation within 3 months of follow-up after treatment and before treatment between two groups.Results After treatment,the levels of serum inflammatory factors and neuron specific enolase in both groups improved compared to before treatment,and the levels of various indicators in the observation group were significantly better than those in the control group(P<0.05).During the follow-up period after treatment,the number and duration of seizures in both groups were significantly less than before treatment,and the observation group was significantly less than the control group(P<0.05).The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).There was no significant difference in the incidence of drug adverse reactions between the two groups(P>0.05).Conclusion The combination of edaravone and sodium valproate in the treatment of post-stroke epilepsy is safe and effective,which can actively control epilepsy symptoms,reduce inflammatory reactions,and is worthy of promotion and use.