Observation on the Effect of Cervical Loop Electrosurgical Excision Procedure Combined with Local Application of Interferon to Treat Low Grade Squamous Intraepithelial Lesions Caused by High-Risk Human Papillomavirus Infection
WANG Qian
Abstract：Objective To explore the effect of loop electrosurgical excision procedure(LEEP)combined with recombinant human interferon-α-2b(IFN-α-2b)gel on low grade squamous intraepithelial lesions(LSIL)caused by high-risk human papillomavirus(HR-HPV)infection of the cervix.Methods One hundred and sixty patients with LSIL caused by HR-HPV infection admitted to Maternal and Child Health Hospital of Lintao in Dingxi from January 2019 to December 2023 were randomly divided into a control group and a combination group,with 80 cases in each group.The control group was treated with LEEP,while the observation group added IFN-α-2b gel on the basis of the control group for local treatment.The improvement of inflammatory factors and the outcome of HR-HPV infection between two groups after treatment were compared.Results After 3 months of treatment,the levels of TNF-α,IL-6,IL-8 and IL-10 in the combined group were lower than those in the control group,while the levels of IL-17 and IL-23 in the combined group were significantly higher than those in the control group(P<0.05).The negative rate of HR-HPV in the combined group was higher than that in the control group after 3 months,6 months and 9 months of treatment,while the recurrence rate of HR-HPV was lower than that of the control group after 12 months of treatment(P<0.05).Conclusion The combination of LEEP and IFN-α-2b gel could further improve the inflammatory status of LSIL patients caused by HR-HPV infection,and further increase the infection conversion rate and reduce the recurrence rate.
Keywords：High Risk Human PapillomavirusLow Grade Squamous Intraepithelial LesionsLoop Electrosurgical Excision ProcedureInterferon
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 65-67,71 )