The Diagnostic Efficacy of Thin-Prepcytology Test Combined with HPV-DNA Detection for Cervical Diseases
SHI Yongcan
Abstract：Objective To explore the diagnostic efficacy of thin-prepcytology test(TCT)combined with human papillomavirus(HPV)test for cervical diseases.Methods Three-hundred and twenty female patients who underwent cervical disease examinations at Jinxiang County People's Hospital from January 2020 to December 2023 were selected,and all patients underwent TCT and HPV-DNA examinations simultaneously.Using colposcopy examination as the gold standard,diagnostic consistency and diagnostic efficacy of combined examination and individual examination were compared.Results The Kappa of TCT diagnosis was 0.250,with ordinary diagnostic consistency.The Kappa of HPV-DNA diagnosis was 0.423,with moderate diagnostic consistency.The Kappa of joint diagnosis was 0.855,with good diagnostic consistency.The sensitivity of joint diagnosis is 92.9%,which was higher than 61.7%of TCT and 68.4%of HPV-DNA.The specificity of combined diagnosis was 93.5%,which was higher than 64.5%of TCT and 75.8%of HPV-DNA.The diagnostic accuracy of joint diagnosis was 93.1%,which was higher than 62.8%of TCT and 71.3%of HPV-DNA.The positive predictive value of joint diagnosis was 95.8%,which was higher than 73.3%of TCT and 83.5%of HPV-DNA.The negative predictive value of combined diagnosis was 89.2%,which was higher than 51.6%of TCT and 60.3%of HPV-DNA(P<0.05).Conclusion For the diagnosis of cervical diseases in women,TCT combined with HPV-DNA examination has good consistency compared to colposcopy examination,and the diagnostic efficacy of the combined examination is better than that of individual examination.
Keywords：Thin-Prepcytology TestHPV-DNA DetectionCervicalScreeningDiagnostic Efficacy
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 58-60,64 )