The Observation on the Effect of Platelet Rich Plasma as an Adjuvant Therapy for Patients with Knee Osteoarthritis
SUN Feng
Abstract：Objective To observing the effect of platelet rich plasma as an adjuvant therapy for patients with knee osteoarthritis.Methods A total of 124 patients with knee osteoarthritis admitted to the People's Hospital of Boxing County of Shandong Province from January 2021 to January 2023 were selected and randomly divided into surgery group and combined group,with 62 cases in each group.The operation group was treated with arthroscopic debridement,while the combined group was treated with platelet-rich plasma on the basis of the operation group.The clinical efficacy,knee range of motion and pain,knee function,and inflammatory factor levels in joint fluid before and 6 months after operation were compared between the two groups.Results After 6 months of surgery,the total effective rate of the combination group was higher than that of the surgical group(P<0.05).The Western Ontario and McMaster Universities osteoarthritis index score of the joint group was lower than that of the surgical group(P<0.05).The levels of interleukin-1β,matrix metalloproteinase-3,basic fibroblast growth factor and tumor necrosis factor-αin knee Joint fluid of combined group were lower than those of the surgical group(P<0.05).Conclusion The use of platelet rich plasma as an adjuvant therapy for patients with knee osteoarthritis has a significant effect,which can further improve knee joint function,and inflammatory cytokine levels in joint fluid.
Keywords：Knee OsteoarthritisPlatelet-Rich PlasmaArthroscopic DebridementFunctionInflammatory Factor
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 51-53,57 )