Effect of Haima Yizhi Powder on Hippocampal Volume Regulation in Patients with Mild Vascular Cognitive Dysfunction of Kidney Deficiency and Phlegm Stasis Type

LI Wei; WU Didi; LI Jiangtao

doi:10.3969/j.issn.1672-7185.2024.07.016

Abstract：Objective To study the modulating effect of Haima Yizhi Powder on the hippocampal volume of patients with mild vascular cognitive dysfunction with renal deficiency and phlegm stasis evidence.Methods A total of 80 patients with vascular cognitive dysfunction with renal deficiency and phlegm stasis evidence admitted to the Department of Encephalopathy of Urumqi Hospital of Traditional Chinese Medicine from January to December 2022 were selected as the study subjects,and they were randomly divided into 40 cases each in the control group and the puzzle group.The control group was treated with aspirin enteric-coated tablets,and the puzzle group was treated with Haima Yizhi powder on the basis of the control group.The changes in neuropsychological assessment before and after treatment and the volume of hippocampal structure after treatment were compared between the two groups.Results After treatment,the mental state score,cognitive function score,memory function and executive ability score,daily life ability score,ischemic condition score,and clinical dementia condition score of the puzzle group were significantly better than those of the control group(P<0.05).After treatment,the left hippocampus volume(3.24±0.07)cm3 and the right hippocampus volume(3.27±0.13)cm3 of the puzzle group were significantly larger than those of(2.51±0.23)cm3 and(2.50±0.22)cm3 of the control group,respectively(P<0.05).Conclusion Haima Yizhi Powder can improve the mental state and cognitive ability of patients,improve memory and executive ability,enhance the ability of daily life,reduce the occurrence of ischemia,reduce the risk of dementia,and improve the clinical efficacy in the treatment of mild vascular cognitive dysfunction of renal deficiency and phlegm stasis type.